Breast Cancer Biology

07 Jun

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The Biology of Breast Cancer Predoctoral Training Program is a multidisciplinary predoctoral training program in tumor biology. The focus of this training program is to provide an educational environment that stimulates excellence in scientific thought and training while simultaneously providing exposure to all of the major fields of study relevant to breast cancer. Our goal is to provide students in the the training program with a solid and uniquely multidisciplinary knowledge base in the current study of breast cancer. A second goal of this program is to stimulate new working alliances between students and staff participating in breast cancer related research, education, and clinical endeavors within the Mayo Cancer Center. Research and training in the program is broadly focused on gene regulation, cell cycle control, cancer genetics, oncogene and tumor suppressor action, tumor immunology, signal transduction, antitumor pharmacology, and the application of this information primarily to the biology of breast cancers. Students participate in laboratory-based research, as well as in a formal tumor biology curriculum that integrates current concepts in cell growth control with the natural history of breast cancer and other human tumors.Breast Cancer Cell Line Database

The database is by no means a complete and exhaustive review of all publications of these eleven cell lines. This project was undertaken by a graduate student (EVL), in addition to the work for a M.S. thesis, and completed in the summer of 2000. More recent publication may add to or contradict some of the entries in the database. Conflicting data was included if found and references are provided to allow the reader to make his/her own conclusions. The hope is that other researchers can use this as a tool to begin their own search for information about breast cancer. Ideally we would like the database to continue and be updated, possibly with submissions from other users; for now please respond with comments, feedback or corrections if discrepancies are found.

Biology of Breast Cancer: A Predoctoral Training Program

The three campuses of the Mayo Graduate School provide an advanced clinical and research training environment for conducting an integrated. multidisciplinary, predoctoral training program based in the study of cell and molecular biology of breast cancer. Thirty-two full-time faculty members currently participate in Mayo’s didactic tumor biology training curriculum which supports the training of postdoctoral trainees in NCI sponsored postdoctoral training programs at Mayo. This strong multidisciplinary tumor biology curriculum provides the foundation for the didactic component of a specialized predoctoral training program in breast cancer. The development of this new training program has been facilitated through the development of two new graduate courses in the cell and molecular biology of breast cancer, as well as through the initiation of a new journal club and an intramural research workshop for trainees in this training program. The research training component of this new predoctoral track is laboratory-based and is fostered by Mayo’s highly competitive and interdisciplinary research environment and by the heightened interest in breast cancer research stimulated through the recent development of the Mayo Women’s Cancer Program within the Mayo Cancer Center.

Race differences in breast cancer due to biology

Differences in how many Hispanic and Caucasian women are diagnosed with breast cancer may be the result of biological factors rather than differences in access to healthcare services, according to findings published in the journal Cancer.

Previous research has shown that the average Hispanic woman who is diagnosed with breast cancer has different characteristics that the average non-Hispanic white women, Dr. Tim Byers, of the University of Colorado Health Sciences Center, Denver, and colleagues write.

A malignant tumor can invade surrounding tissue and destroy it. Cancer cells also can break away from a malignant tumor and enter the bloodstream or lymphatic system. This is how cancer spreads within the body. When breast cancer spreads outside the breast, cancer cells often are found in the lymph nodes under the arm. Cancer cells may spread beyond the breast such as to other lymph nodes, the bones, liver or lungs Although it is not common, some patients whose underarm lymph nodes are clear of breast cancer may still have cancer cells which have spread to other parts of the body.